Oncogenes: An Introduction to the Concept of Cancer Genes by Kathy B. Burck,Edison T. Liu,James W. Larrick,Joshua

By Kathy B. Burck,Edison T. Liu,James W. Larrick,Joshua Lederberg

"Cancer viruses" have performed a paradoxical function within the historical past of melanoma study. came across in 1911 by way of Peyton Rous (1) on the Rockefeller Institute, they have been principally missed for a number of a long time. Witness his eventual reputation for a Nobel Prize, yet no longer until eventually 1966-setting an all time list for latency, and testimony to at least one extra benefit of sturdiness. within the Nineteen Fifties, one other Rockefeller Nobelist, Wendell Stanley, spearheaded a crusade to concentration cognizance on viruses as etiological brokers in melanoma, his plat­ shape having been the chemical characterization of the tobacco mosaic virus as a natural protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was once a centerpiece of the U.S. nationwide melanoma campaign of 1971: if human cancers have been brought on by viruses, the critical job was once to isolate them and get ready vaccines for immunization. At that time, many observers felt that maybe an excessive amount of cognizance used to be being dedicated to melanoma viruses. It was once not easy even if viruses performed an etiological function in additional than a handful of human cancers.

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